A Novel Drug can Help ‘Un-excite’ an Anxious Brain, Suggests a Recent Study

Being anxious is a common response to a situation where someone experiences stress or emotional turmoil. It is a situation in which people have a strange sense of dread, fear, or restlessness. It may lead to a condition where people, vulnerable to emotional stress, start experiencing a heightened state of anxiety, in which they grapple to manage with their feelings leading to the development of an anxiety disorder.

Anxiety disorder is a condition characterized by a debilitating fear when there’s no real reason for being worried or anxious. While a lot of research has been done in this field and helpful drugs like selective serotonin reuptake inhibitors (SSRI) are being prescribed to improve this condition, researchers are continuously engaged in understanding more about this complicated mental disorder.

In the similar sphere, researchers from Tokyo University of Science and University of Tsukuba have come up with a new development. Previously, the same researchers had suggested the use of KNT-127, a drug that helped activate particular receptors in the brain known as “delta opioid receptors.”

KNT-127 reduces anxiety

Now the researchers, who conducted the experiment on mice, have presented evidence that advocates the anxiety-reducing property of KNT-127. They have found that KNT-127 can help reduce the action of glutamate, which is an excitatory neurotransmitter. In simple words, KNT-127 acts on that section of the brain that dominates emotional health and can help alleviate anxiety.

“The medial prefrontal cortex (mPFC) plays a vital role in the processing of emotional events. It has been shown that activation of the glutamatergic transmission in PL-PFC evoked anxiety-like behavior in rodents,” said Professor Akiyoshi Saitoh, from the Faculty of Pharmaceutical Sciences, Tokyo University of Science.

In the nutshell, the study proposes a prospective novel drug that can be considered for treating anxiety disorder and can help millions of people across the world improve their quality of life.

Talking about the clinical significance of drugs like KNT-127, Dr. Daisuke Yamada, one of the prominent researchers, laid emphasis on the need for exploring new agents with unique and better means than the drugs prescribed and used today.

Dealing with anxiety

Feeling anxious at times, especially during stress hours, can be normal feeling. Some simple practices can help people alleviate anxiety in normal circumstances.

People who are vulnerable to anxiety should:

  • Limit alcohol and caffeine and eat balanced meals.
  • Get adequate sleep as it helps the body relax. Aim for at least 8 hours of sound night sleep.
  • Learn and practice relaxation techniques like meditation and yoga. Other simple things like listening to music can also help.
  • Take time out to exercise daily. Exercising can help relieve stress and anxiety.
  • Know their triggers and look for patterns. It can help people deal with their anxiety better.
  • Spend time with their dear ones. Sharing feelings with them and asking for their support can be an effective way to manage anxiety.

These are some of the self-help techniques that can help you deal with your anxious state of mind. However, if symptoms persist or intensify over time, professional help may be required. The 24/7 Mental Health Helpline is a useful online resource to seek information and immediate help related to mental health conditions and treatment centers. Contact over online chat or call at our 24/7 Helpline (855) 653-8178 for round-the-clock outpatient mental health help. We assure you prompt and effective assistance.